Influence of chromium (III), cobalt (II) and their mixtures on cell metabolic activity
نویسندگان
چکیده
Abstract Chromium (III) and cobalt (II) are necessary elements required for the proper functioning of organism, but their excess can cause toxic effects. They basic components implants also commonly used in medicine as dietary supplements, vitamin mineral products energy drinks. The aim this study was to investigate effect chromium combination on BJ cells. In study, cells were exposed CoCl 2 or CrCl 3 at concentrations ranging from 100 1400 µM, cytotoxicity mixtures assessed by MTT reduction, LDH release NRU assays. outcome work reveals cytotoxic effects assays, low , stimulation cell proliferation observed. higher concentrations, viability decreased tested line all During simultaneous incubation fibroblasts with 200 µM 1000 antagonism observed: concentration induced protection toxicity; case interaction chloride µm protective not latter case, synergism between these noted. Our indicates that show properties. These metals have a destructive membrane, lysosomes mitochondria, which leads disorders metabolism.
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ژورنال
عنوان ژورنال: Current Issues in Pharmacy and Medical Sciences
سال: 2021
ISSN: ['2084-980X', '2300-6676']
DOI: https://doi.org/10.2478/cipms-2021-0019